A Twist on Potassium Channel Gating
نویسندگان
چکیده
The selectivity filter of potassium channels, the narrowest segment of the pore, permits only potassium ions to diffuse through the pore. Clarke et al. (2010) now present 11 structures of an inwardly rectifying potassium channel, providing evidence that the selectivity filter functions in channel gating and conformational changes in the cytoplasmic domains correlate with pore opening.
منابع مشابه
Gating Behavior of Endoplasmic Reticulum Potassium Channels of Rat Hepatocytes in Diabetes
Background: Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic...
متن کاملEvidences on the existence of a new potassium channel in the rough endoplasmic reticulum (RER) of rat hepatocytes
Introduction: we have recently reported the presence of two potassium currents with 598 and 368 pS conductance in the rough endoplasmic reticulum (RER) membrane. The 598 pS channel was voltage dependent and ATP sensitive. However, the 368 pS channel was rarely observed and its identity remained obscure. Since cationic channels in intracellular organelles such as mitochondria and RER play imp...
متن کاملBiophysical properties of single potassium channel in the brain mitochondrial inner membrane of male rat with Alzheimer’s disease
Introduction: Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by impairment of memory and changes in behavior and personality. Recent evidence suggests that mitochondrial channels play important roles in memory disorders. Accordingly, the biophysical properties of a single potassium channel were investigated in the brain mitochondrial inner membrane of rat with...
متن کاملRuled surface underlying KcsA potassium channels.
Recent experiments have revealed that the opening and closing of the channel is controlled by concertedly rotating and tilting the ends of the alpha-helices in the KcsA ion channels. We recognize these transmembrane alpha-helices as the generating lines of the ruled surface: the hyperboloid of one sheet. The twist-to-shrink feature of the hyperboloid is adopted by KcsA channels in gating the po...
متن کاملSolution-Based Single-Molecule FRET Studies of K(+) Channel Gating in a Lipid Bilayer.
Ion channels are dynamic multimeric proteins that often undergo multiple unsynchronized structural movements as they switch between their open and closed states. Such structural changes are difficult to measure within the context of a native lipid bilayer and have often been monitored via macroscopic changes in Förster resonance energy transfer (FRET) between probes attached to different parts ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 141 شماره
صفحات -
تاریخ انتشار 2010